2-[(4-氨基-1H-吡唑并[3,4-d]嘧啶-1-基)甲基]-5-甲基-3-(2-甲基苯基)-4(3H)-喹唑啉酮 (S,R,S)-AHPC-C6-NH2 dihydrochloride 6-氨基-N-[3-[4-(4-吗啉基)吡啶并[3',2':4,5]呋喃并[3,2-D]嘧啶-2-基]苯基]-3-吡啶甲酰胺 (S,R,S)-AHPC-PEG2-NH2 dihydrochloride Apitolisib (GDC-0980) (S)-4-氨基-N-(1-(4-氯苯基)-3-羟基丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-羧酰胺 E3 ligase Ligand-Linker Conjugates 38 氨磷汀硫醇 Pomalidomide-PEG1-azide 4-氯-3,5-二硝基三氟甲苯 (S,R,S)-AHPC-C10-NH2 dihydrochloride APG-115 (S)-4-氨基-N-(1-(4-氯苯基)-3-羟基丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-羧酰胺 Dactolisib PIK-90 奥米利塞 A 410099.1, amine-Boc hydrochloride E3 Ligase Ligand-Linker Conmaugates 24 TFA Duvelisib Ipatasertib GNE-317 Tideglusib 6-(1H-吲哚-5-基)-4-(4-吗啉基)-1-[1-(3-吡啶基甲基)-4-哌啶基]-1H-吡唑并[3,4-D]嘧啶 (S,R,S)-AHPC-Me-C5-COOH Palomid 529 2-[[(1R)-1-[7-甲基-2-(4-吗啉)-4-氧代-4H-吡啶并[1,2-A]嘧啶-9-基]乙基]氨基]苯甲酸 LY-2584702对甲苯磺酸盐 LY-2584702自由基 PF-4708671 [5-[7-甲磺酰基-2-(吗啉-4-基)-6,7-二氢-5H-吡咯并[2,3-D]嘧啶-4-基]嘧啶-2-基]胺 AZD1080 哌立福新 Milademetan N-ETHYL-N'-[4-[5,6,7,8-四氢-4-[(3S)-3-甲基-4-吗啉基]-7-(3-氧杂环丁基)吡啶并[3,4-D]嘧啶-2-基]苯基 A-674563 叔丁基二硫 维妥色替 西罗莫司脂化物 LY2090314 PIK-75 LY2090314 TG 100713 AKT 激酶抑制剂 PI3K-IN-1 A 66 2-吗啉代-8-苯基色酮 GSK2334470 TG 100713 SB 216763 CAY10505 TIC10异构体 ZSTK474 PF-4708671 4-十二烷基-N-1,3,4-噻二唑-2-基苯磺酰胺 2-氨基-N-[2,3-二氢-7-甲氧基-8-[3-(4-吗啉基)丙氧基]咪唑并[1,2-C]喹唑啉-5-基]-5-嘧啶甲酰胺 BML-275 AT7867 6-氨基-N-[3-[4-(4-吗啉基)吡啶并[3',2':4,5]呋喃并[3,2-D]嘧啶-2-基]苯基]-3-吡啶甲酰胺 3,3'-(2,4-二氨基-6,7-蝶啶二基)二苯酚 E3连接酶Ligand-Linker共轭物18 蛋白激酶B抑制剂 SB 415286 E3 ligase Ligand-Linker Conjugates 21 PIK-294 AZD-8055 (S,R,S)-AHPC-C2-NH2 dihydrochloride TDZD-8 BX 795 奥米利塞 VS-5584 OSI-027 Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride (S,R,S)-AHPC-PEG3-propionic acid PKI-402 TWS119 OSI-027 Torkinib N-[5-[4-氯-3-[[(2-羟基乙基)氨基]磺酰基]苯基]-4-甲基-2-噻唑基]乙酰胺 GSK 3抑制剂IX (S,R,S)-AHPC-C5-NH2 hydrochloride E3 ligase Ligand-Linker Conjugates 40 2-甲基-3-丁烯-2-醇 OSU-03012 IC-87114 AZD2858 BI-D1870 (S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride Pomalidomide-PEG4-C2-NH2 hydrochloride OSU-03012 PI-3065 都灵1 MK-2206 dihydrochloride (5Z)-5-[[4-(4-吡啶基)-6-喹啉基]亚甲基]-2,4-噻唑烷二酮 WZ4003 AZD-8055 E3 ligase Ligand 17 hydrochloride 5-(6-喹喔啉亚甲基)-2,4-噻唑啉二酮 E3连接酶Ligand-Linker Conjugates 12 Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride BI-D1870 哌立福新 Thalidomide-NH-C4-NH-Boc E3连接酶Ligand-Linker共轭物6 CCT128930 Thalidomide-O-amido-C4-NH2 hydrochloride PIK-75 吉达利塞 PDK1抑制剂 VH032-PEG1-NH2 dihydrochloride BX912 红海海绵素 A AS-252424 Thalidomide-O-C6-NH2 TFA 艾代拉利司 Pomalidomide-amido-C3-COOH (S,R,S)-AHPC-C4-NH2 dihydrochloride E3连接酶配体-连接体共轭25个三氟乙酸盐 2-甲基-1-[[2-甲基-3-(三氟甲基)苯基]甲基]-6-(4-吗啉基)-1H-苯并咪唑-4-羧酸 E3 ligase Ligand-Linker Conjugates 33 Hydrochloride Tideglusib Pomalidomide 4'-alkylC5-acid NSC59984 E3连接酶Ligand-Linker共轭物7 E3连接酶Ligand-Linker共轭物16 SB 216763 Thalidomide-NH-PEG2-C2-NH-Boc [7-(6-氨基-3-吡啶基)-2,3-二氢-1,4-苯并氧氮杂卓-4(5H)-基][3-氟-2-甲基-4-(甲基磺酰基)苯基]-甲酮 (S,R,S)-AHPC-C8-NH2 Pilaralisib类似物 4-[(5-溴吡啶-2-基)氨基]-4-氧代丁酸 (S,R,S)-AHPC-Me-C10-NH2 E3 ligase Ligand-Linker Conjugates 49 E3 Ligase Ligand-Linker Conjugates 1 Pomalidomide-PEG6-butyl iodide E3 ligase Ligand-Linker Conjugates 33 E3连接酶Ligand-Linker共轭物11 Thalidomide-O-PEG2-propargyl MDM2-IN-1 4-[(5-溴吡啶-2-基)氨基]-4-氧代丁酸 AZD1080 Thalidomide-O-C6-NH2 CCT128930 N-[4-[4-(4-吗啉基)-1-[1-(3-吡啶甲基)-4-哌啶基]-1H-吡唑并[3,4-D]嘧啶-6-基]苯基]氨基甲酸甲酯 WZ4003 5-(2-氨基-8-氟[1,2,4]三唑并[1,5-A]吡啶-6-基)-N-(叔丁基)-3-吡啶磺酰胺 2-(1H-吲唑-4-基)-6-[[4-(甲基磺酰基)-1-哌嗪基]甲基]-4-(4-吗啉基)噻吩并[3,2-D]嘧啶 Afuresertib Nutlin 3 (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride E3 ligase Ligand-Linker Conjugates 36 Pifithrin-α, p-Nitro, Cyclic 3-Hydroxy Midostaurin Thalidomide-NH-PEG2-C2-NH2 hydrochloride BX 795 3-[3-[2-(生物素酰胺)乙基]氨基-3-氧代丙基]二硫基]丙酸琥珀酰亚胺酯 KU-0063794 E3 ligase Ligand-Linker Conjugates 30 2-氨基-N-[2,3-二氢-7-甲氧基-8-[3-(4-吗啉基)丙氧基]咪唑并[1,2-C]喹唑啉-5-基]-5-嘧啶甲酰胺 4,6-二氯吡啶-3-酰胺 5-[(2,2-二氟-1,3-苯并二恶茂-5-基)亚甲基]噻唑烷-2,4-二酮 沙帕色替 MHY1485 Pifithrin-β AMG 925 HCl Thalidomide-O-C6-NH2 hydrochloride 2-氨基-3-氟-5-氯吡啶 H-89二盐酸盐 E3 Ligase Ligand-Linker Conjugates 2 Thalidomide-O-amido-PEG-C2-NH2 hydrochloride Thalidomide-O-C4-NH2 hydrochloride 4-[6-[4-[(甲氧羰基)氨基]苯基]-4-(4-吗啉基)-1H-吡唑并[3,4-D]嘧啶-1-基]-1-哌啶羧酸甲酯 IM-12 Thalidomide-NH-PEG3-propionic acid FN-1501 BML-275 TAK-659 PROTAC MDM2 Degrader-1 9-(6-氨基-3-吡啶基)-1-[3-(三氟甲基)苯基]苯并[H]-1,6-萘啶-2(1H)-酮 TWS119 AZD2858 双(3-氰基丙基)二甲氧基硅烷 Gilteritinib hemifumarate FLT3-IN-4 AR-A014418 N-[4-[1-(1,4-二氧杂螺[4.5]癸烷-8-基)-4-(8-氧杂-3-氮杂双环[3.2.1]辛烷-3-基)-1H-吡唑并[3,4-D]嘧啶-6-基]苯 E3 ligase Ligand-Linker Conjugates 34 Hydrochloride GNE-8505 SCH529074